Treatment of early caries lesions using biomimetic self-assembling peptides--a clinical safety trial.

A highly significant improvement in the global impression of change was recorded at day 30 compared with baseline (p <0.001).

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For lesion size and progression, there was an increasing trend towards improvement over the first eight days after treatment but this was not statistically significant until D30, where lesion size was judged to have significantly decreased (p <0.05) and lesion progression was judged to have moved from arrested/progressing to remineralising (p <0.01).

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