In another meta-analysis that included 57 studies of postmenopausal women randomized to HT or control (PBO or calcium/vitamin D) for at least 1 year, there was a nonsignificant trend toward a reduced incidence of vertebral (RR, 0.66; 95% CI, 0.41–1.07; 5 trials) and nonvertebral fractures (RR, 0.87; 95% CI, 0.71–1.08; 6 trials) with HT and consistent, favorable effects on BMD [ 31 ].
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The tissue selective estrogen complex: a promising new menopausal therapy.
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