The 5'-3' exoribonuclease Pacman (Xrn1) regulates expression of the heat shock protein Hsp67Bc and the microRNA miR-277-3p in Drosophila wing imaginal discs.

The effect of controlled RNA turnover on gene expression can be extremely significant, for example, some studies have shown that 40–50% of changes in gene expression occur at the level of RNA stability. 1 In multicellular organisms, it is increasingly evident that degradation of specific mRNAs is critical for the regulation of many cellular processes, including early development, in

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