However, the administration of temsirolimus induced growth inhibition of both ACHN/P and ACHN/R tumours, and the growth inhibitory effect of temsirolimus on the ACHN/P tumour was highly significant, compared with that on the ACHN/R tumour.
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Acquired resistance to temsirolimus in human renal cell carcinoma cells is mediated by the constitutive activation of signal transduction pathways through mTORC2.
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