Relationship between the COMT-Val158Met and BDNF-Val66Met polymorphisms, childhood trauma and psychotic experiences in an adolescent general population sample.

Testing for gene x environment interaction was borderline significant in the case of COMT-Val158Met with individuals with the COMT-Val158Met Val-Val genotype, who had been exposed to childhood trauma borderline significantly more likely to report psychotic experiences than those with Val-Met or Met-Met genotypes.

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The borderline significance of the interaction between COMT genotype and childhood trauma indicates that chance should be considered a possible explanation of this interaction, though the test for interaction is conservative, making this less likely.

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