This leads to the generation of tumor specific effector T-cells capable of recognizing and eliminating tumor cells.[ 78 ] Several researchers have investigated the distribution of LCs in squamous cell carcinoma, however, none have yielded consistent results, some observed an increase[ 12 79 ] while few observed a decrease[ 80 81 ] in LC density, whereas some observed no change at all.[ 82 ] The number of LCs infiltrating the tumor site is regarded as a highly significant prognostic parameter in patients with oral squamous cell carcinoma.
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