Barely Significant
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Aging is associated with highly defined epigenetic changes in the human epidermis.

Epigenetics Chromatin · 2013 · PMC3819645 · PMID 24279375

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highly significantP = 9.63 × 10 -4actually significant
In addition, functional annotation of differentially expressed genes also showed a highly significant enrichment of genes involved in the development of the epidermis ( P = 9.63 × 10 -4 ), which also included downregulation of SPRR1A and B, KRT16 and KRT17 in old samples.

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