A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth.

This disease profile contrasts sharply with targeted mouse models of PSACH-MED in which there are highly significant differences in the extractability of numerous cartilage structural proteins including various collagens, small leucine-rich proteoglycans and tenascins ( supplementary material Table S2 ) ( Bell et al., 2013 ).

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