Transcriptional basis for the inhibition of neural stem cell proliferation and migration by the TGFβ-family member GDF11.

PLoS One · 2013 · PMC3820543 · PMID 24244313

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hedged sentences

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp <10 −83actually significant

GDF11 and the EGF receptor inhibitor AG1478 regulated a common set of 2466 probes, with a highly significant ( p <10 −83 ) r value of 0.37.

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an overall trendno p-value reported

The GDF11 transcriptional response displays an overall trend towards a downregulation of pro-migratory genes (Rac GEFs, regulators of actin and microtubule dynamics) and upregulation of anti-migratory genes (Rho GEFs, stabilizers of cell-cell junction and adhesion to the extracellular matrix) in NSCs.

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