Based on this criterion, the PWM from the 246 donor splice sites is highly significant.
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Position weight matrix, gibbs sampler, and the associated significance tests in motif characterization and prediction.
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The sentences
With α 0 = 0.05, α = α 0 /986 = 0.00005081 which requires a PWMS value equal to 1.292076814 to be marginally significant, given μ = 0.068884, and σ = 0.314714254.