borderline significantp = 0.06
In the LOAD group the percentage MEPE positive area was higher in the tibia that had received mechanical loading compared to its contralateral left tibia as is shown in Figure 2a , the difference between the loaded tibia and the control tibia being borderline significant (1.48 ± 0.59 vs 0.92 ± 0.33; p = 0.06) After repeated mechanical loading of the right tibia for two weeks no difference in percentage MEPE positive area between the loaded tibia and the control tibia was observed (0.62 ± 0.36 vs 0.62 ± 0.33; Figure 2c ).