TAP mediates import of Mycobacterium tuberculosis-derived peptides into phagosomes and facilitates loading onto HLA-I.

Coupling of UL49.5-NP directly to the Mtb resulted in a modest (16%) but highly significant decrease in IFN-γ release by D160 1–23, in comparison to UL49.5-SCR coupled Mtb, while recognition by D454 E12 was not affected ( Figure 4 ).

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