Tonic stimulation of the pharyngeal mucosa causes pain and a reversible increase of inflammatory mediators.

Inflamm Res · 2013 · PMC3826052 · PMID 24037371

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failed to reach significanceno p-value reported

In contrast, a previous study found significant increases in PLT in nasal lavage fluid when cold dry air was applied to the nasal cavity, although increases in PGE 2 and TXB failed to reach significance [ 10 ].

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