The 6-minute walk test and other clinical endpoints in duchenne muscular dystrophy: reliability, concurrent validity, and minimal clinically important differences from a multicenter study.

31 , 32 When interpreting clinical measures, it is important to consider that, although small changes may be significant statistically, they may not be relevant clinically. 31 , 33 Numerous methods to derive the MCID have been described. 31 , 32 , 34 – 44 These include anchor-based methods, 31 , 36 , 39 , 40 which compare a patient's change score with another measure of clinically relevant change, and distribution-based methods, 36 , 41 – 43 such as the standard error of measurement (SEM), effect size, and one third the standard deviation (SD) at baseline, which are built on the statistical distribution and psychometric properties of the measure in a population.

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