Enhancement of tight junctional barrier function by micronutrients: compound-specific effects on permeability and claudin composition.

The highest quercetin concentration (400 μM) (in a 48 hr exposure) caused a 20% increase in R t that was highly significant (P<0.001).

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A 200% increase was also observed for claudin-7, though not quite statistically significant (P = 0.06; the lack of statistical significance [P>0.05] was likely due to the relatively small sample size [n = 3 cell layers], and the strong effect that a small sample size has on Student t test results).

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