CCL3L1 copy number, HIV load, and immune reconstitution in sub-Saharan Africans.

There is a small but marginally significant difference (p = 0.02, t-test) between the mean copy number of the Ethiopian HIV-only and the HIV-TB co-infected cohort, although this is not replicated in the smaller Tanzanian cohort (p = 0.69).

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While such studies are based on reasonable hypotheses concerning the function and interaction of proteins and pathogens, the marginal significance levels and limited power of such studies means that drawing definitive conclusions regarding the role of genetic variation remains difficult.

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