Diffusion tensor imaging of nigral degeneration in Parkinson's disease: A region-of-interest and voxel-based study at 3 T and systematic review with meta-analysis.

We found a highly significant PD induced nigral FA reduction with an estimated weighted pooled disease effect size of − 0.90 (p < 0.0001, Forrest plot see Fig. 2 , values of individual studies see the supplements, Inline Supplementary Table S2 ).

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