highly significantp-value < 0.001
The second in the psychological domain (Are you capable of accepting your physical appearance?) showed that Hb SS patients said they were more willing to accept their physical appearance than the Hb SC group (p-value > 0.05). The applicability of the WHOQOL-BREF to measure quality of life in sickle cell disease The correlation between the WHOQOL-BREF questions and the mean score of each of its domains varied from 0.492 to 0.759, thus presenting a highly significant correlation between the scores of each of the six domains (p-value < 0.001) The internal consistency of the WHOQOL-BREF as measured by Cronbach's alpha coefficient was satisfactory on considering all items of the score (0.88), as well as separately, by 'physical' (0.78), 'psychological' (0.64), 'social relations' (0.54), and 'environmental domains' (0.71), and 'general QOL' (0.51) ( Table 3 ).