Variability in functional p53 reactivation by PRIMA-1(Met)/APR-246 in Ewing sarcoma.

Br J Cancer · 2013 · PMC3833220 · PMID 24129240

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near significanceno p-value reported

In the wild-type p53 cell line TC252, expression of the pro-apoptotic gene Puma as well as the classical p53 target cdkn1A /p21 WAF1 were all enhanced upon APR-246 treatment with cdkn1A /p21 WAF1 levels reaching near significance ( Figure 3B ).

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