Both mature miR-17-5p and passenger strand miR-17-3p target TIMP3 and induce prostate tumor growth and invasion.

Although the miR-17-3p inhibitor (17-3pI) did not show any effects, the miR-17-5p inhibitor (17-5pI) enhanced p21 and PTEN expression ( Figure 10 d, middle for vector cells and right for miR-17 cells). DISCUSSION The ability of prostate cancer to invade and metastasize are highly significant and allow prostate cancer cells to migrate through the extracellular matrix (ECM), which is composed of a wide variety of proteoglycans, glycoproteins, proteins and hyaluronan.

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