Barely Significant
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Reducing heart failure admission rates in England 2004-2011 are not related to changes in primary care quality: national observational study.

Eur J Heart Fail · 2013 · PMC3834843 · PMID 23845798

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highly significantno p-value reported
However, these effects were small and did not explain the large and highly significant annual trend in falling admission rates.

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may be significantno p-value reported
There may be significant variation between the willingness of practices to up-titrate medication to the maximum tolerated dose and to ensure maximum patient concordance, which this analysis was unable to measure.

also in 13,097 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.