An update on the molecular actions of fenofibrate and its clinical effects on diabetic retinopathy and other microvascular end points in patients with diabetes.

After 5 years of fenofibrate treatment, the main FIELD study found a highly significant overall 31% reduction in the need for the first laser treatment for any retinopathy, with a number needed to treat of just 17 to avoid at least 1 individual requiring laser among those with known DR at study entry ( 1 ).

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