Programmed cell death-4 deficiency prevents diet-induced obesity, adipose tissue inflammation, and insulin resistance.

At the end of the study, plasma TG and TC levels in HFD-fed PDCD4 −/− mice were markedly lower than those in WT obese mice, and fasting plasma glucose levels had a decreasing trend, although no significant difference was observed during HFD intervention ( Fig. 2 A – C ).

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