an increasing trendP = 0.035
In addition, Lin et al ., observed that, among maintenance hemodialysis patients, the GSTM 1 null genotype was associated with a significantly lower antioxidant capacity than the GSTM+ genotype.[ 20 ] The null/low polymorphisms of the GSTM 1 and GSTT 1 genes have been associated with the risk of developing ESRD in North Indian patients.[ 17 ] In addition, Singh et al ., reported that patients with transplant therapy demonstrated an increasing trend toward carrying the GSTM 1 null genotype (51.3%) versus healthy controls (40.4%) with a risk of about 1.5-fold ( P = 0.035), and patients with a variant genotype of GSTM 1 were at the higher risk of transplant rejection.[ 21 ] The frequencies of important functional mutations and alleles result in broad ethnic variation.