The lymphocyte apoptosis which accompanies neutrophil apoptosis may be significant in pathogenesis of IMD by disrupting the T-B lymphocyte activation and interaction required for generation of bactericidal antibody. 6 7 We have obtained preliminary confirmation of virus-associated lymphocyte apoptosis using flow cytometric assessment of annexin-V binding 30 in IM, which showed enhanced binding by CD4, CD19, and especially CD8, but not natural killer lymphocytes (Smith H, unpublished).
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Virus-associated apoptosis of blood neutrophils as a risk factor for invasive meningococcal disease.
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