Baseline high viral load and unfavorable patterns of alanine aminotransferase change predict virological relapse in patients with chronic hepatitis C genotype 1 or 2 obtaining rapid virological response during antiviral therapy.

In addition to HVL, this study found that unfavorable patterns of ALT change (i.e., an increasing trend of ALT between weeks 4 and 12 and/or between weeks 12 and 24 [end-of-treatment]) after HCV-RNA clearance was also independently related to VR, especially in the subgroup with HVL, regardless of G-1 or G-2 status, receiving Peg-IFN-α-2b.

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