Both positive and negative selection pressures contribute to the polymorphism pattern of the duplicated human CYP21A2 gene.

This stunning difference in the numbers of sites of the three site classes were highly significant between intron 2 and the remaining part of the gene (χ 2 : p=0.0055, power=1.0000), and the differences between the subregions were also statistically significant (intron 2 vs. non-cds without intron 2, χ 2 : p=0.0106, power=1.0000, intron 2 vs. cds, χ 2 : p=0.0091, power=1.0000, cds and non-cds without intron 2, χ 2 : p=0.0423, power=0.9989).

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