Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease.

Immunostaining with an antibody directed against EndoG and subsequent quantification of EndoG-immunoreactive nuclei in the substantia nigra in controls and individuals with PD revealed a highly significant difference: While ∼40% of the nuclei in nigral neurons of PD patients displayed either dense or granular EndoG immunoreactivity, only ∼17% stained positive for EndoG in age-matched healthy controls ( Figure 7F and G ).

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