Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2.

Carcinogenesis · 2013 · PMC3845892 · PMID 23892603

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highly significantno p-value reported

EPA was far more selective than DHA causing 2.5-fold (premalignant) to 3.5-fold (malignant) more growth inhibition than in their normal counterparts at a dose of 3 μM and 4-fold (malignant) to 6-fold (premalignant) at 5 μM (a highly significant difference), as compared with DHA, which caused only 1.5-fold (premalignant: not significant) to 2-fold (malignant) more growth inhibition at a dose of 3 μM.

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