24 Corpechot et al compared liver stiffness as determined by transient elastography (FibroScan®; Echosens, Paris, France) to histological findings obtained by liver biopsy in patients with PBC or primary sclerosing cholangitis, and showed a highly significant correlation of liver stiffness with both degree of fibrosis and histological stage. 25 Recently the same group did a prospective performance analysis of transient elastography for the diagnosis of METAVIR fibrosis stages in a cohort of 103 PBC-specific patients as compared to the previous one. 26 Their study confirms the diagnostic performance and accuracy of transient elastography in the noninvasive quantification of liver fibrosis in PBC.
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