BMP4 inhibits the proliferation of breast cancer cells and induces an MMP-dependent migratory phenotype in MDA-MB-231 cells in 3D environment.

A highly significant decrease in cell number was evident at day 3 and day 6 (42% and 50%, respectively, as compared to vehicle; P < 0.01).

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At day 14 the difference was 28% but just failed to reach statistical significance (Figure 3 C).

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