Wild-type but not mutant SOD1 transgenic astrocytes promote the efficient generation of motor neuron progenitors from mouse embryonic stem cells.

The percentage of eGFP+ MNs was increased by a fold-change of 2.8, compared to the control (p <0.001) (Figure 2 j), consistent with previous findings that wt non-Tg astrocyte CM results in a highly significant increase in differentiated MNs [ 15 ].

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