In the EJC-independent NMD mode, mini-μ C3/H4 ter440 mRNA levels were restored to wt mRNA levels in the SMG6/SMG7 double knockdown, and β-Globin Δintron2 ter39 mRNA showed a highly significant 4.7-fold up-regulation ( Fig. 5 B).
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Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways.
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