Gene Expression Meta-Analysis Identifies Cytokine Pathways and 5q Aberrations Involved in Metastasis of ERBB2 Amplified and Basal Breast Cancer.

19 However, our finding that the TNFR2 metagene is associated with survival in basal-like and nonbasal-like cancers in both the training set and test set (borderline significance for the nonbasal-like tumors in the test set) strongly indicate the prognostic disadvantage of low TNFR2 pathway expression.

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For ERBB2 tumors, the low expression of 5q33 (borderline significant; Fig. 3A ) and interleukin (IL)-12 ( Fig. 3E ) were associated with poor outcomes, which was in agreement with the GSEA meta-analysis.

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