Location and dynamics of the immunodominant CD8 T cell response to SIVΔnef immunization and SIVmac251 vaginal challenge.

While the abundance of Mamu-A1/Tat-specific tetramer + cells did not increase significantly following vaginal challenge, either in LTs or cervical vaginal tissues, there was a marginally significant increase in Mamu-A1/Tat-tetramer + Ki67 + cells following challenge in cervical vaginal tissues, consistent with a recall response ( Figure 7C ).

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