These results showed highly significant enrichment of NUYTTEN_EZH2_TARGETS_UP , which includes genes up-regulated in PC3 cells following EZH2 knockdown [ 16 ], indicating that DAC treatment may erase methylation marks from Polycomb EZH2 marked loci and subsequently activate genes involved in differentiation (Fig. 4D ).
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Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.
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