Genetic variation in the extended major histocompatibility complex and susceptibility to childhood acute lymphoblastic leukemia: a review of the evidence.

Front Oncol · 2013 · PMC3859964 · PMID 24377085

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highly significantno p-value reported

Further, a highly powered study of children with medically refractory ALL, those being considered for or going to stem cell transplantation, has revealed highly significant associations to both HLA class I ( HLA-A and - B ) and class II ( HLA-DRB1 ), results which may shed light on the role of HLA in the less severe disease form of pediatric ALL.

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