Metabolomics of the tumor microenvironment in pediatric acute lymphoblastic leukemia.

For example, glutamine, which would be expected to be strongly affected by l -asparaginase, a component of the drug treatment, showed a highly significant decrease after the first week of treatment ( Tables S4 and S5 in File S2 , Figure S11 in File S1 ; PB day 0 versus day 8; pFDR=0.0122), but increased by the end of therapy (PB day 8 versus day 29; pFDR=0.0133) almost to the same concentration measured at diagnosis (PB day 0 versus day 29; pFDR=0.1750).

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