Plasma omega-3 PUFA and white matter mediated executive decline in older adults.

O3PUFA associated with better executive function (Tails B, β = −1.15, p = 0.025, Figure 2C ), however, after adding WMH as a “mediating” variable into the regression equation that included O3PUFA, age, APOE4 and total intracranial volume simultaneously as predictors of executive function, the significant association between O3PUFA and better executive function was lost (β = 0.54, p = 0.332, Figure 2D ) and the WMH association with executive dysfunction remained marginally significant (β = 3589.95, p = 0.056, not illustrated in the Figure).

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