Deep sequencing-based transcriptional analysis of bovine mammary epithelial cells gene expression in response to in vitro infection with Staphylococcus aureus stains.

For example, the 4 h postinfection GO analysis of the three Control-infected library pairs showed highly significant upregulations in the nitric oxide synthase (NOS) genes of the S178-, S56- and S36- infected pBMECs libraries relative to the control, with log2 ratios of 2.57, 0.14 and 1.03 respectively: Nitric oxide (NO) is produced in cells in response to infections and plays a vital role in the early innate immune response that kills pathogens [50] .

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