Gender differences among children with autism spectrum disorder: differential symptom patterns.

An increasing trend in Northern European populations in the 18th and early 20th centuries shifted to a markedly decreasing trend from the latter half of the 20th century until the present. 20 , 21 Sudden downward shifts seen in small populations associated with environmental and occupational chemical exposures are consistent with a male disadvantage in responding to toxic burdens. 22 A study of adults with Asperger's syndrome found 24 biomarkers distinguishing affected males from controls and 17 different analytes distinguishing females from controls.

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