For both the fore- and hindlimbs in Fz3 −/− embryos, several findings emerge: (1) the thinning of the dorsal nerve is highly significant statistically and it occurs over a remarkably small interval, between the regions labeled D Proximal and D Distal in Figure 4M ; (2) proximal to position D Proximal , dorsal nerve thinning is minimal and statistically insignificant; (3) the ventral nerve exhibits a small decrease in thickness in 5/
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Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons.
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