Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.

However, assessing both GWS and suggestive variants outside the HLA region, we observed a direct PPI network consisting of 9 proteins with 6 direct interactions ( P =0.0007) and mean associated protein direct connectivity of 1.33 (expected=0.63, P =0.048) in addition to an indirect network that exhibited a mean associated protein indirect connectivity trending toward significance ( P =0.082) ( Supplementary Figures 27 and 28 ).

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