Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia.

PLoS Genet · 2013 · PMC3868543 · PMID 24367274

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Remarkably, by simply selecting all genes having a candidate somatic mutation in at least two samples (213 genes in total), we already achieved a highly significant enrichment for T-ALL related genes, such as NOTCH1 , BCL11B , FBXW7 , DNM2 , JAK3 , JAK1 , and IL7R .

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