However, it is not impossible to imagine (among other things) that DNA binding is much tighter when ComP is within Tfp and that a minor binding defect of DUS C4G undetectable in vitro might be significant enough in vivo for the bound DNA not to be taken up efficiently, which is supported by a very recent study [33] (see Note added in proof).
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Functional analysis of the interdependence between DNA uptake sequence and its cognate ComP receptor during natural transformation in Neisseria species.
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