29 , 42 The SEARCH genome-wide association study found no evidence for significant associations between other SLCO1B1 SNPs and simvastatin-induced myopathy, but in haplotypes with rs4149056 there was an association of borderline significance (P=0.03) between the G allele of the functional variant rs2306283 (c.388A>G) and lower risk of myopathy. 8 The effect of the rs2306283 polymorphism on the transport function of OATP1B1 is variable in different studies and may be substrate-specific. 44 In some studies it has been found to be associa
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