Statistical optimization and in vitro evaluation of metformin hydrochloride asymmetric membrane capsules prepared by a novel semiautomatic manufacturing approach.

Coefficients with t -value of effect above Bonferroni line are designated as certainly significant coefficients, and coefficients with t -value of the effect between Bonferroni line and t limit line are termed as coefficients likely to be significant, while t -value of effect below the t limit line is statistically insignificant and should be removed from the analysis [ 17 ].

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