Low frequency variants, collapsed based on biological knowledge, uncover complexity of population stratification in 1000 genomes project data.

PLoS Genet · 2013 · PMC3873241 · PMID 24385916

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likely to be significantno p-value reported

In more traditional case/control analyses, large bins are less likely to be significant because increasing binsize generally means more noise to mitigate the signal.

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an interesting trendno p-value reported

Our results show an interesting trend between functional regions of the genome and variant tolerance.

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