Proof of concept, randomized, placebo-controlled study of the effect of simvastatin on the course of age-related macular degeneration.

Smoking was also less prevalent in the placebo group; the difference was marginally significant (χ 2 df = 1 = 3.5, p = 0.06) ( Table 2 ).

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Logistic regression analysis stratified by Y402H genotype showed a highly significant 12-fold reduction in AMD progression in the group assigned to simvastatin if they were homozygous for the at risk C allele at Y402H of the CFH gene [OR = 0.08 (95%CI 0.02, 0.45), p = 0.004], but not in the combined group of CT and TT genotypes (p = 0.74) ( Table 5 ).

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