Consumption of a large meal increased the number of c-Fos positive cells in controls and mutants, respectively, in the AP (681%, P < 0.01; 213%, P = 0.06), NTS (2,095%, P < 0.01; 606%, P < 0.01), and DMV (2,065%, P < 0.01; 458%, P < 0.01), although this increase failed to reach significance for SM22α-NT-3 KO mice in the AP (cf.
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Loss of neurotrophin-3 from smooth muscle disrupts vagal gastrointestinal afferent signaling and satiation.
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